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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43dc432369c3f19ac57bd6be5d48f84c150859cbaac0129a173cb1da4c5e69cd' 
  AND token = 'pS+O7Ofn+m8NK7r1U0hzNJTFyW2zAzk9aWqPX2gVIFA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}