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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4a7372b96897772bd97aa9d9ee21e9ea1963bb15b8bc857ffebdcab688529e48' 
  AND token = 'MJ5E+jrqdB4YcgD7KWALiWq70QQodJCQ3KmC0eYYvtM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}