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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3b49b2947dadce51994810e3f6aee3902adec172c76d2fce4828f81a5e400a95' 
  AND token = 'Fwyhk2Fbp43DMHoVNs8F+JPDTAKDszrmbES0RfDm5sw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}