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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4a181b83523e219d9a3c324c48d44654433267252e3aafb4b11b8175845621cf' 
  AND token = 'VA36jnYC+r/yhFoAlk/MWg82B5FyS5tmemJJoP40pW4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}