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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22aa6f387af1595e8bdda01b1fa197c3326e3102d7a772010483363776a03602' 
  AND token = '+2WZ/0sYfthZvJWGZBY/yWAm4Up98MbHBGkWhwcHDiI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}