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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6a52b49acfe783d44cd1adac575b60a0dd4a47c531c2fbf1e687d8107b1d5e32' 
  AND token = 'pixa3CGRPvUT5fuNyqD2JqZLUYbbZo5LXhxDvhCSxkE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}