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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '80f0ab8a068a5625729014a38451ad807bd441bb147f52bf59aaf8beb1838591' 
  AND token = 'ZiL3frSjfTajLWG0tWzK/XiVlbXkqlPQ4eXQ/dSP6Sw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}