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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '46e54efa19023a7e578a9a8dd05c1fb00cf7ce3b84dbfbb8e9a95d9b034d6cb5' 
  AND token = 'p6uL7Z1CkZyoFxSxSsx+IL7fJNg+dCr1ZdPq5hns4YM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}