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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '187c1b56bc68fe8bcee64fe8cc75229a548423336a5968d9aebac31dd6cfc318' 
  AND token = '4jDT9pe/fWsnR0uX+SWSdfzH3q4pntrAZ0YeeQXXylo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}