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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '81df0b616b61eae698b5bef4a12d5ce5f28727636ccc269a33505b652c46dafc' 
  AND token = 'hmlwdDz8Wihy4H7YNNG9lLL2dqJnDEwrZ3uvJoEtp38=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00032

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}