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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '18b34d13e105dd497dd0d7e3b62c109a1bb639c6f636a6697b310befbfd39060' 
  AND token = '5dZQUMhv0Ay/CB/Bg4h//s9pgjqJ/dMqkmAAmrGcHHY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}