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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49c8d3dd31e802c9732da782ae2596cb52554e62ce20d356f86d81d59d0a76a4' 
  AND token = 'u8+caMoJAkOCI4nTfz60vCcwd6RjkrdSxZNk9cfrYbU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}