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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e22c146e19fcbf5a23dc693d2eeb86c0e133d29855e21cde3a627203c0c0f10f' 
  AND token = 'Exni6AH76Zw50eeS8eQ94Yx/nLamw3swboeJrL3bLT0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}