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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4b6241fcb8672120a1aadc82c04b8935d6d450c5b4caa60cb9ac5ccb40ee902f' 
  AND token = 'p1nRwMXYp5z6c6/1t5NZ1CV4yySbKAGAgNKXsltZUcA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}