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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e5d452b62c6038e6eedf5328f0f0784b9de2ca5159df91776f22b01b88dfccfb' 
  AND token = '+5IR0QRNXbwCenH1xpIWe+wkj2bvRS6B6ijMzNfJvt8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}