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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1e253d61d98ffdd81c9a96782a5cb3d7ba98fbea7f946fa674f55b31188db32c' 
  AND token = 'X7Y+Xik0LtisdLq84jBG0dz2aZKidzjXY6a4qsPt3SQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}