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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f5f53fbfdbca655cd4ff6fb1633c695377c96fd4135f9b16125071801fee66b6' 
  AND token = 'EQ2wJ6cNNuwOkmo9b1pze4+4PSgWlm8UeMFnrqxmHXY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}