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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '021254a4980b949fd9ceb4635a8f015aafce3d4b50f2bb6e27830d935f1fa177' 
  AND token = 'lN0RkP3ynjd0Oa3R7pGOAbLOZmRAXiVMPrD0O2laEYI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}