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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1a32a04783f8fdf3b2f46efb5172ddb63e62589a298ef9a0d77e8dd810d5e507' 
  AND token = 'F8yiLLxd8P1NEYkoQiCjiQdIxbyxf0+HUs8eOY5Y7tc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}