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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '25444861a032df829351b2f1f53b4cc6f14d8021fb8d06e60b571a49af1d915f' 
  AND token = '+l/gdcHu54xdqxoW/UHVUBFC/V8chuIRw8tsyeNTVU0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}