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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '73c225c0e8abbd718e875b4713ece68a2a9cc2ca97aecce48d926b7f505b44cc' 
  AND token = 'tnYYFsSM7O7PsIv3ddp1wc+R7HfF2JwLBFwcrK0bKv0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}