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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8c52f8b8396704c00e7c6e153bf5204958b19490fe4b068c75f142980e1f0a3d' 
  AND token = '+eCWexs4h8sPPCEpyi8QtO/fkRamHC9/EJRngse/2ag=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}