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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '45392921616941f008a681046de2995a2912dc8b5d3e3c99bc4203e3eac725c4' 
  AND token = '8QJUYJ1OCZQOFBE+XcArAvlzJ4i+XAZbJ3IzXCotjnw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}