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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4af7e479dead822ea7836ddb752e3f42751ad9c01020ec5f6fa96c7f970d3032' 
  AND token = 'MdDry+qILjRiPPdnGUmPruS+LDGw/rG4ONyKZRUTc9Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}