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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '946c5c4e2811da2b75b76d49eebd02142208d170b9a430330f5d2c964c50970a' 
  AND token = 'NcQaaDpOHH0AWG3HVGWl+3gD7YD4AJk2kf7Z6gKKjBk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}