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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '002e44bba1e62b406c5fc8228cfeb96f6bf2abf8ce7985c31b04de410630f7b8' 
  AND token = 's2pxhb4EIyKI2SlA+//SjXkseaW2Sz4bgnh5SUwq30E=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}