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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '046cfab5d31b75c628a6589ee644ceddb4892a252f246153d92bcced41948be5' 
  AND token = 'tSL0KLm+fQYhXcTuOI+/l9x2OuAWYkYWt84iaRb54yk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}