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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b8161463d055f0411d5cb57be51d1ac0853dd4ddb568a4489874b7700e30da42' 
  AND token = 'TlcjZL0vCo2B+SC1t5eV7pgT6qZ6i6PYILdBH5rTWQY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}