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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4e667de654c88b457951d2cf6ce80f089e3e3c4edd090ba455f052bb1557cab7' 
  AND token = '2/qQoVVN5Afsh5XNUuHxgG5TgvBMV4MK6jfIGM8M6Us=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}