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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '25788e76d89996a27a63ab9e1aa161baa2570db46041f128d34abdf2c51af240' 
  AND token = 'faBJ2DoS0Mk2mXD099J8aWlcHeFe4LDdXCNvXN2QfuY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}