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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '75bd34a8d1b871ff337196b9f176fce45734db1a2d605d38dfc05777635ae6c5' 
  AND token = 'npk15rdV1vFuHpPrG7smLwDwgWmnrjkwHdlBTpaRw3g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}