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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '46d3382459aa0e98765e092c4397e7a819a61809f6b627295adf527dc4e1b483' 
  AND token = 'iy7KfZxIVgyxsiqtwoNs0elVvvy9OrwV0FxpwX+3R/M=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}