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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c843493aeb2bb55806231af84c60fb677731254cb705b94c6b0f2a65dfa75647' 
  AND token = 'VZPDTfWZ5NWLd/6w6rCAr1pdh8M2a8FoLp9SO9560Aw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}