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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78e2628fad085b1c3ce74c929fb8a4a8dceef179cd8d8e54a42ffb58416a583a' 
  AND token = 'eKpBwWg+0CDe0VhaPTcqPgYEiv0uXzH5otaCyzFKAcc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}