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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '45b15dc066eef5ae7a4b8ef066862d6cad80de430b3c84b0b1311f49252ea327' 
  AND token = 'igziCsOX4MhsfxoDqVpCopUlsZFCqoHH6mmOmxfLY3k=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}