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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f29df3456abc917e0ae92efa07db7aa9d6c1740a4c16564171740e029f8d2ff9' 
  AND token = 'd9gQ3f+WiQqdHVQOuhgEyGwN2qkD0hMECHHRcp4QQ1w=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}