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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43d0d5e1a90b5dfa963d644b89ed09191343478ee7bfa36b4665f08ac0c86549' 
  AND token = 'rjWUXd51ihr/D8lzOD4U3/biJyGMFEQLzF/CI3/2/wY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}