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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2ccb7ca2420e5e199d449e1424b85dc3f3b9caf807326d7d5c86c0de83c50f8a' 
  AND token = 'c/P46pNdkM/j0poVjQGB/7LmLxDrHaKlDdTG1+0S1Bc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}