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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '48b5107bb97ed9ae5db2e637e138654ea728fe1e0b64ecd4849283b85eadabfd' 
  AND token = 'prWPMmkBCguIUj4/kKxLGo19aYkYSMeevTtXqzFgJXI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}