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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4ad5ddd89b1b20c24260c39f6c5cf6eb4fbbe0fb28f664dd4bf78e823393c6d4' 
  AND token = 'pF+10/3ycc7rOcD/cutalTbzN062Tp4YKTJAZNENJxY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}