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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e3221c06286976a0aea2a0d91df867f2b607b7152a57e929f707e2b1ec323a3d' 
  AND token = 'P6cNcgfuwy/nro+ZFBwx48/wqdhJoEaoj7XsSPkdqBk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}