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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1781a955eb271a734beb94aa5ac9fd3efa3a379d4f1c3da0e489b30d341f206a' 
  AND token = 'k2JE7hwnBNf3wan1hW4efSslv5hDjI5GfjkhtspWhz0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}