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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd255203744583779fa9e69128cb791d7e8cbc9f02331a6e37ae70bf9f9b79bbb' 
  AND token = 'bUPM+3kql54LILQBX3UAgzNmkpTyj4RNIy+EHyF0lPs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}