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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21833f0a4091c2369da3b2b5e5f1f1ff40e79462bfe31232aed746d9c1d1d3b9' 
  AND token = '0+FkWgGvFA4dFT5kDPUWUoNMfmDM0Pi3PYCfxNJlCQY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}