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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a57b6e7d0a5cd84dc8e494aab1bede29a2cc611b7b0539c2c58b630a267da210' 
  AND token = 'ag2UTQTU6rW4o+4k1RTEJsP7vuUPEc175sWAVkb4IbQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}