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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2cd144d4ee71af3e85ab152e14427449cc8a1c77a64efc249c84ac146116f750' 
  AND token = 'ERj77S4XkUuxDs7dYk+4RMxdOvfgCt1tvsjM5UcKIWk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}