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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '889b61405f0d051ae0fda43be7d2d62fcbe89d63581d4aaa010b4f11c6f07244' 
  AND token = '/iTc6bEBzA6a4XYVnHGZ8TYLZmvT+jbWONcc6Y3Ql/M=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}