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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '741da4f4a7e8ebf61fd2af8df4789af2f7f0ca8d712c22b467f6a1879b55ed84' 
  AND token = '1LJdwUM9PdmloTH6ZjXzJ8FWjBdY6XISs4PXcR/MhRQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}