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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ad5c451f90887a75628978c4b4c66b99dacb7fb430a1acc53894b5a42eafde27' 
  AND token = 'azVS82fCkaN5jtRQE+WkqYvYwul5g8Y8QE68as4kBVg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}