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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '15ac0649ee2bcd3db9bcae0851e36e418451a4b2c430c736c10ff9d3d794a5c8' 
  AND token = 'km130k827IqEdNupU6+S3h76rQhHHZgpedutwo+7BFA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}